publicações selecionadas
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artigo de revista
- 2-Styrylchromones as inhibitors of α-amylase and α-glucosidase enzymes for the management of type 2 diabetes mellitus. Medicinal Chemistry Research. 2024
- Transition Metal‐Catalyzed Transformations of Chalcones. Chemical Record. 2024
- Steroid–Quinoline Hybrids for Disruption and Reversion of Protein Aggregation Processes. ACS Medicinal Chemistry Letters. 2022
- Inhibition of the carbohydrate-hydrolyzing enzymes a-amylase and a-glucosidase by hydroxylated xanthones. Food & Function. 2022
- The Antioxidant Activity of Prenylflavonoids. Molecules. 2020
- A study towards drug discovery for the management of type 2 diabetes mellitus through inhibition of the carbohydrate-hydrolyzing enzymes a-amylase and a-glucosidase by chalcone derivatives. Food & Function. 2019
- Cholesterol-Based Compounds: Recent Advances in Synthesis and Applications. Molecules. 2019
- A comprehensive review on xanthone derivatives as a-glucosidase inhibitors. European Journal of Medicinal Chemistry. 2018
- First intramolecular Diels-Alder reactions using chromone derivatives: Synthesis of chromeno[3,4-: B] xanthones and 2-(benzo [c] chromenyl)chromones. New Journal of Chemistry. 2018
- First intramolecular Diels–Alder reactions using chromone derivatives: synthesis of chromeno[3,4-b]xanthones and 2-(benzo[c]chromenyl)chromones. New Journal of Chemistry. 2018
- 1,6-Conjugate Additions of Carbon Nucleophiles to 2-[(1E ,3E )-4-Arylbuta-1,3-dien-1-yl]-4H -chromen-4-ones. European Journal of Organic Chemistry. 2017
- An Overview of 2-Styrylchromones: Natural Occurrence, Synthesis, Reactivity and Biological Properties. European Journal of Organic Chemistry. 2017
- 2-[(1E ,3E )-4-Arylbuta-1,3-dien-1-yl]-4H -chromen-4-ones as Dienes in Diels-Alder Reactions - Experimental and Computational Studies. European Journal of Organic Chemistry. 2017
- 2,3-Diarylxanthones as potential inhibitors of Arachidonic acid metabolic pathways. Inflammation. 2017
- Synthesis of chromone-related pyrazole compounds. Molecules. 2017
- Arylxanthones and arylacridones: A synthetic overview. Pure and Applied Chemistry. 2016
- Characterization of 2,3-diarylxanthones by electrospray mass spectrometry: gas-phase chemistry versus known antioxidant activity properties. Rapid Communications in Mass Spectrometry. 2016
- Novel chromone and xanthone derivatives: Synthesis and ROS/RNS scavenging activities. European Journal of Medicinal Chemistry. 2016
- (E)-2-(4-Arylbut-1-en-3-yn-1-yl)chromones as Synthons for the Synthesis of Xanthone-1,2,3-triazole Dyads. European Journal of Organic Chemistry. 2015
- Inhibition of NF-kB Activation and Cytokines Production in THP-1 Monocytes by 2-Styrylchromones. Medicinal Chemistry. 2015
- Chalcones as versatile synthons for the synthesis of 5- and 6-membered nitrogen heterocycles. Current Organic Chemistry. 2014
- Chalcones as versatile synthons for the synthesis of 5- and 6-membered nitrogen heterocylces. Current Organic Chemistry. 2014
- Synthesis and transformation of halochromones. Current Organic Synthesis. 2014
- Electrochemical characterization of bioactive hydroxyxanthones by cyclic voltammetry. Tetrahedron Letters. 2013
- Six-membered ring systems. With O and/or S atoms.. Progress in Heterocyclic Chemistry. 2013
- Six-Membered Ring Systems: With O and/or S Atoms. Progress in Heterocyclic Chemistry. 2012
- Synthesis and structure elucidation of novel pyrazolyl-2-pyrazolines obtained by the reaction of 3-(3-aryl-3-oxopropenyl)chromen-4-ones with phenylhydrazine. Arkivoc. 2012
- Tetrahydroquinazoline-substituted chromones from Diels-Alder reaction of (E)-2-styrylchromones and pyrimidine ortho-quinodimethane. Tetrahedron Letters. 2012
- The dependence of a-tocopheroxyl radical reduction by hydroxy-2,3-diarylxanthones on structure and micro-environment. Organic and Biomolecular Chemistry. 2012
- Structure-activity relationships in hydroxy-2,3-diarylxanthone antioxidants. Fast kinetics spectroscopy as a tool to evaluate the potential for antioxidant activity in biological systems. Organic and Biomolecular Chemistry. 2011
- Synthesis of Novel 1-Aryl-9H-xanthen-9-ones. Synlett. 2011
- 2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: A structure-activity relationship study. Bioorganic & Medicinal Chemistry. 2010
- Anti-inflammatory potential of 2-styrylchromones regarding their interference with arachidonic acid metabolic pathways. Biochemical Pharmacology. 2009
- Dimethyldioxirane oxidation of exocyclic (E,E)-cinnamylideneketones. Australian Journal of Chemistry. 2009
- Efficient syntheses of new polyhydroxylated 2,3-diaryl-9H-xanthen-9-ones. European Journal of Organic Chemistry. 2009
- Cyclic voltammetric analysis of 2-styrylchromones: Relationship with the antioxidant activity. Bioorganic & Medicinal Chemistry. 2008
- 2-Styrylchromones: Novel strong scavengers of reactive oxygen and nitrogen species. Bioorganic & Medicinal Chemistry. 2007
- A novel and efficient route for the syntheses of hydroxylated 2,3-diarylxanthones. Synlett. 2007
- Epoxidation of (E,E)-cinnamylideneacetophenones with hydrogen peroxide and iodosylbenzene with salen-MnIII as the catalyst. European Journal of Organic Chemistry. 2007
- Epoxidation studies of 2-styrylchromones using Jacobsen's catalyst and hydrogen peroxide and iodosylbenzene as oxidants. Journal of Heterocyclic Chemistry. 2006
- New Synthesis of 2,3-Diarylxanthones. Synlett. 2005
- Hepatoprotective activity of polyhydroxylated 2-styrylchromones against tert-butylhydroperoxide induced toxicity in freshly isolated rat hepatocytes. Archives of Toxicology. 2003
- Synthesis of New Hydroxy-2-styrylchromones. European Journal of Organic Chemistry. 2003
- 2-Styrylchromones as novel inhibitors of xanthine oxidase. A structure-activity study. Journal of Enzyme Inhibition and Medicinal Chemistry. 2002
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artigo de conferência
- Analysis of the antidiabetic potential of natural xanthones through the inhibition of a-amylase and a-glucosidase activities 2022
- Analysis of the antidiabetic potential of natural xanthones through the inhibition of α-amylase and α-glucosidase activities 2022
- Inhibition of pancreatic a-amylase activity by a group of hydroxyxanthones 2020
- Inhibition of pancreatic α-amylase activity by a group of hydroxyxanthones 2020
- Modulating protein aggregation in cell models using modified steroids 2019
- Synthesis and in vitro a-glucosidase inhibitory activity of polyhydroxylated 2-styrylchromones 2019
- Synthesis and in vitro α-glucosidase inhibitory activity of polyhydroxylated 2-styrylchromones 2019
- Design, synthesis and preliminar antioxidant evaluation of new hydroxy- chromone and xanthone derivatives 2018
- Evaluation of in vitro anti-diabetic potential of 2, 3-diaryb(anthones through the inhibition of a-glucosidase 2018
- Chromones as versatile building blocks in cycloaddition reactions 2017
- Conjugate additions of carbon nucleophiles to chromone derivatives towards nitrogen heterocycles 2017
- Conjugate additions of carbon nucleophiles to chromones substituted with extended p-systems at C-2 2017
- Conjugate additions of carbon nucleophiles to chromones substituted with extended π-systems at C-2 2017
- Microwave-assisted synthesis of chromeno[3,4-b]xanthones and (benzo[c]cromenyl)chromones 2017
- Nitromethane conjugate addition to 2-[(1E,3E)-4-arylbuta-1,3-dien-1-yl]-4H-chromen-4-ones 2017
- Nitromethane conjugate addition to 2-[(1E,3E)-4-arylbuta-1,3-dien-1-yl]-4Hchromen- 4-ones 2017
- Total fat content and fatty acid profile of pseudocereals 2017
- 2-[(1E,3E)-4-Arylbuta-1,3-dien-1-yl]-4H-chromen-4-ones as dienes in Diels–Alder reactions: experimental and computational studies 2016
- Arylxanthones with anti-inflammator potential in cellular systems 2016
- Chromone derivatives as novel dienes in Diels-Alder reactions 2016
- Composição química da folha e do caule de Calamintha baetica 2015
- Análise dos critérios de rotulagem de produtos alimentares comercializados em São Tomé e Príncipe 2015
- Recent developments in the synthesis of novel xanthone-1,2,3-triazole dyads 2015
- Synthesis of xanthone-1,2,3-triazole dyads 2015
- The antioxidant activity of novel chromones and xanthones: a structure-activity relationship 2015
- 2-(4-Arylbuta-1,3-dien- or 1-en-3-yn-1-yl)chromones as synthons for the synthesis of other nitrogen and oxygen heterocyclic compounds 2014
- Propriedades nutricionais e bioativas do cultivar de colza Hydromel 2014
- Síntese de novas cromonas e xantonas com atividade captadora de espécies reativas de oxigénio 2014
- Synthesis of (E)-2-(4-Arylbut-1-en-3-ynyl)-4H-chromen-4-ones 2013
- Synthesis of 2-{2-[5(4)-aryl-2H-[1,2,3]-triazol-4(5)-yl]vinyl}chromen-4-ones 2013
- The response of rapeseed cultivar hydromel to nitrogen fertilization: chemical composition and antioxidant capacity 2013
- Efeito da adubação azotada na composição química de sementes de colza da cultivar hydromel 2012
- Electrochemical behavior of Hydroxyxanthones versus ROS scavenging activities 2012
- Electrochemical characterization of hydroxylated xanthones by cyclic voltammetry 2012
- New syntheses of novel arylxanthones 2012
- Polyhydroxylated 2-styrylchromones and –xanthones as potent antioxidante agentes 2012
- Structure determination of some oxygen and nitrogen heterocyclic compounds by NMR 2012
- Synthesis of Benzo[a]naphtho[2,3-c]xanthones from 2-styrylchromones 2012
- Synthesis of novel 2-Butadienylchromone derivatives 2012
- Novel Hydroxy-9H-xanthen-9-ones derivatives: synthesis and bioactive properties 2011
- Metodologias para avaliar a actividade captadora de espécies reactivas de oxigénio e de azoto envolvidas no processo inflamatório 2010
- NDPO2 as a selective generator of 1o2 used in the scavenging activity assay of 2,3-diarylxanthones 2010
- ROS and RNS Scavenging Activity by 2,3-Diarylxanthones 2010
- Recent developments in the synthesis of 1-aryl-9H-xanthen-9-ones 2010
- Studies towards the synthesis of polyhydroxyxanthones with potential antioxidant activity 2010
- The 2-styrylchromone structure is an effective scaffold for the development of new inibitors of the nf-kb pathway 2010
- Anti-inflammatory potencial of 2-Styrylchromones regarding their interference with arachidonic acid metabolic pathways 2008
- Cyclic voltammetric analysis of 2-styrylchromones 2008
- Incorporation of 2-styrylchromones in liposomes: preliminaries studies 2008
- Novel 2-Styrylchromones with high anti-inflammatory potencial through prevention of LTB4 production by human leukocytes, inhibition of COX-1 activity and scavenging of ROS and RNS 2008
- Polyhydroxy-2,3-diarylxanthones as antioxidants 2008
- The ROS and RNS scavenging activity of 2-Styrylchromones are effectively repreoduced by cyclic voltammetry analysis 2008
- Inhibition of Leukotriene B4 production in human Neutrophils by 2-Styrylchromones 2007
- Interactions of 2-Styrylchromones with pro-inflamatory enzymes and oxidative species 2007
- Polyhydroxy-2,3-Arylxanthones: a total synthesis 2007
- A novel route for the synthesis of 2,3-Diarylxanthones 2006
- Epoxidation of (E,E)-Cinnamylideneacetophenones Using Salen Mn(III) as Catalyst 2006
- NMR in the epoxidation of (E,E)-Cinnamylideneacetophenones 2006
- Singlet oxygen scavenging activity by 2-Styrylchromones 2006
- Synthesis of 2,3-Arylxanthones using palladium catalysts 2006
- Synthesis of Polyhydroxy-2,3-diarylxanthones with potencial antioxidant activity 2006
- Nitric oxide and superoxide radical scavenging of 2-Styrylchromones 2005
- Synthesis of 2,3-Distyrylchromones 2005
- Synthesis of new xanthone derivatives 2005
- Epoxidation of 2-Styrylchromone derivatives 2004
- Epoxidação de (E,E)-Cinamilidenoacetofenonas com Peróxido de Hidrogénio 2004
- Epoxidation Studies do 2-Styrylchromones 2003
- Hepatoprotective activity of 2-styrylchromone derivatives against the pro-oxidant hepatotoxic effect elicited by tert-butylhydroperoxide in freshy isolated rat hepatocytes 2003
- Potent Inhibition of Xanthine Oxidase by Novel 2-Styrylchromones 2001
- 2-Styrylchromones with potencial antioxidant activity 2000
- NMR studies on the antiradical mechanism of phenolic compounds towards 2,2-diphenil-1-pycridrazyl radical 2000
- Synthesis and evaluation of the antiradicalar activity of polyhydroxy-2-styrylchromones 2000
- Synthesis of 2-styrylchromones with potencial antioxidant activity 1999
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livro
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capítulo de livro
- Six-membered ring systems: With O and/or S atoms. Progress in Heterocyclic Chemistry. 2024
- Six-membered ring systems: With O and/or S atoms. Progress in Heterocyclic Chemistry. 2023
- 15.4.5 Quinolinones and Related Systems (Update 2022) 2022
- Cholesterol chemistry and laboratory synthesis 2022
- Eight-Membered Rings With One Oxygen Atom 2022
- Quinolinones and related systems (Update 2022) 2022
- Recent advances in the synthesis of 4H-chromen-4-ones (2012 - 2021) 2022
- Six-membered ring systems: with O and/or S atoms. Progress in Heterocyclic Chemistry. 2021
- Six-membered ring systems: with O and/or S atoms 2020
- Six-membered ring systems: with O and/or S atoms 2018
- Six-Membered Ring Systems: With O and/or S Atoms 2017
- Valuable analytical tools in analysis of honeybee plant-derived compounds: nuclear magnetic resonance spectroscopy 2016
- Nuclear magnetic resonance spectroscopy for structural characterization of bioactive compounds 2014
- Six-membered ring systems: with O and/or S atoms 2012
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poster de conferência
- Analysis of the antidiabetic potential of natural xanthones through the inhibition of α-amylase and α-glucosidase activities 2022
- Chromones as versatile building blocks in cycloaddition reactions 2017
- Conjugate additions of carbon nucleophiles to chromone derivatives towards nitrogen heterocycles 2017
- Microwave-assisted synthesis of chromeno[3,4-b]xanthones and (benzo[c]cromenyl)chromones 2017
- Nitromethane conjugate addition to 2-[(1E,3E)-4-arylbuta-1,3-dien-1-yl]-4H-chromen-4-ones 2017
- 2-(4-Arylbuta-1,3-dien- or 1-en-3-yn-1-yl)chromones as synthons for the synthesis of other nitrogen and oxygen heterocyclic compounds 2014
- Synthesis of (E)-2-(4-Arylbut-1-en-3-ynyl)-4H-chromen-4-ones 2013
- Synthesis of 2-{2-[5(4)-aryl-2H-[1,2,3]-triazol-4(5)-yl]vinyl}chromen-4-ones 2013
- The response of rapeseed cultivar hydromel to nitrogen fertilization: chemical composition and antioxidant capacity 2013
- Electrochemical behavior of Hydroxyxanthones versus ROS scavenging activities 2012
- Structure determination of some oxygen and nitrogen heterocyclic compounds by NMR 2012
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teses
- Reações de cicloadição e adição conjugada de cromonas substituídas em C.2 com sistemas insaturados 2017
- Composição química da folha e do caule de Calamintha baetica. Efeito do solvente na extração de compostos antioxidantes 2014
- Efeito da adubação azotada na composição química e propriedades antioxidantes de sementes de colza da cultivar hydromel 2012
- Transformações de cetonas a,ß- e a,ß,¿,d-insaturadas. Novas rotas de síntese de 2,3-diarilxantonas 2007
- Transformações de cetonas a,ß- e a,ß,¿s- insaturadas : novas rotas de síntese de 2,3- diarilxantonas 2007
- Transformações de cetonas α,β- e α,β,γ,δ-insaturadas. Novas rotas de síntese de 2,3-diarilxantonas 2007
- Síntese e avaliação da actividade antioxidante de 2-estirilcromonas 2000
- Síntese e avaliação da actividade antioxidante de 2-estirilcromonas 2000