Synthesis of Polyhydroxy-2,3-diarylxanthones with potencial antioxidant activity
Conference Paper
Overview
Overview
abstract
Xanthones are a well-studied class of heterocyclic compounds [1] and over the years these
substances have been extensively studied due to their biological properties. Both natural and
synthetic derivatives have shown important anti-microbial, anti-tumour, anti-inflammatory as well
as antioxidant activities [2]. Several structure/activity studies of polyphenolic compounds revealed
that the presence of hydroxyl substituents in certain positions of their skeleton is of great
importance for a high antioxidant activity [3].
Taking this knowledge into consideration, we report the synthesis of new polyhydroxy-2,3-
diarylxanthones, starting from the 3-bromo-2-methylchromone 1. Aldol condensation of 1 with
benzaldehydes leads to the formation of 3-bromo-2-styrylchromones 2 followed by Heck reaction
with styrenes to give the 2,3-arylxanthones 3 [4]. The final step consists in the cleavage of
protective groups to obtain the desired polyhydroxy-2,3-diarylxanthones 4
