Electrochemical behavior of Hydroxyxanthones versus ROS scavenging activities

Xanthones are a class of naturally-occurring oxygenated heterocyclic compounds with a broad spectrum of biological activities of great interest for potential therapeutic applications. 1 IJ Thus, over the last decades a great number of publications have emerged focusing on the isolation and s~nthesis of these natural compounds or even in the search for novel bioactive derivatives.1- 1 Electrochemical methodologies can be applied to establish correlations between structure and oxidation potential of electroactive species and therefore to predict some of its biological activities. In fact, cyclic voltammetry has become an important and widely used electroanalytical technique in many relevant studies of redox ~rocesses for clarifying the electrochemical behavior of chemical and biochemical systems.1 1 Herein, we will report the electrochemical behavior of several phenolic and catecholic-substituted 2,3-diarylxanthones by cyclic voltammetry using a glassy carbon electrode, at pH 7.4, and the results obtained compared with their scavenging activities for reactive oxygen species (ROS) and reactive nitrogen species (RNS).141 Useful considerations about oxidation mechanism will be highlighted and the electrochemical profile of xanthones will corroborate their biological propetties.

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