Electrochemical characterization of hydroxylated xanthones by cyclic voltammetry
Conference Paper
Overview
Overview
abstract
Xanthones constitute a class of oxygenated heterocyclic compounds commonly identified in
some higher plant families, fungi and lichens [1]. Their large variety of biological and
pharmacological activities encouraged the scientific community for the search and isolation of
natural derivatives for therapeutic applications [2]. Consequently, extensive studies have been
devoted to the development of synthetic routes for the preparation of these naturally-occurring
compounds or other synthetic bioactive derivatives [3,4].
For the present study, xanthones XH1-9 were obtained by synthesis and the diversity of
substitution pattern includes the presence of phenolic and catecholic moieties. These structural
features are important requisites for the scavenging activity against reactive oxygen and nitrogen
species already demonstrated by these molecules [5].
During the last decades, electrochemical studies have been widely used for the evaluation of
structure-antioxidant activity relationship of several phenolic compounds [6,7]. Thus, the
electrochemical profile of xanthones XH1-9 can provide useful information about their
electrochemical reactions, which may be used to predict or explain their biological properties.
In this communication we will report the electrochemical characterization by cyclic voltammetry
of various hydroxylated xanthones, in physiological conditions. The oxidation potential value
versus structure relationship will be highlighted and some considerations about the oxidation
mechanism will be presented.
