The Antioxidant Activity of Prenylflavonoids uri icon


  • Prenylated flavonoids combine the flavonoid moiety and the lipophilic prenyl side-chain. A great number of derivatives belonging to the class of chalcones, flavones, flavanones, isoflavones and other complex structures possessing di erent prenylation patterns have been studied in the past two decades for their potential as antioxidant agents. In this review, current knowledge on the natural occurrence and structural characteristics of both natural and synthetic derivatives was compiled. An exhaustive survey on the methods used to evaluate the antioxidant potential of these prenylflavonoids and the main results obtained were also presented and discussed. Whenever possible, structure-activity relationships were explored.
  • The authors are grateful to FCT/MEC, Fundação para a Ciência e Tecnologia and Ministério da Educação e Ciência, Portugal and FEDER, the Partnership Agreement PT2020, for financial support to CIMO (UID/AGR/00690/2019) and QOPNA (UID/QUI/00062/2019) as well as project POCI-01-0145-FEDER-016385. Acknowledgments: Thanks are due to University of Aveiro and Instituto Politécnico de Bragança for all support.

publication date

  • January 2020