In 2013, a large variety of publications dedicated to the synthesis 0- and
S-6-membered heterocycles emerged, with special emphasis on the synthesis
of natural oxygen derivatives.
The importance of microwave irradiation in the synthesis of 0 - 6-
membered compounds (14SC3047), the synthesis of several of their natural
derivatives or key intermediates in a gram-scale fashion covering the literature
from the twenty-first century (14NPR419), the isolation, synthesis and
structural elucidation of the natural tetrahydropyran amphidinol 3
(14NPR468) and the chemistry of the secondary metabolite silybin , a
2-aryl-4H-chroman-4-one, were reviewed (14NPR1138).An overview of
the natural occurrence, synthesis and biological properties of chromones
(14CR4960), synthesis and structure-activity relationship of antileishmanial
phenolic natural and synthetic flavonoids, isoflavones, coumarins and xanthones
(14CR1 0369), the synthesis of natural products and natural-productlike
compounds based on chroman-type structures (14SL1953) and the
natural occurrence and synthesis of chromenes, coumarins and fused
chromene-type cmnpounds as well as the application of dihydrobenzo[h]
chromenes in the construction of various synthetic organic compounds
(14CR 1 0476) have also been surveyed.
The synthesis of O- and S-6-membered heterocycles was actively pursued
in 2015. Special emphasis is given to the synthesis of natural oxygen
derivatives.
The chemistry of -oxoesters in the synthesis of O-, S-, and S,Oheterocycles
(15CR151) and of copper-catalyzed C‒H functionalization
reactions to prepare O-heterocycles has been discussed (15CR1622).
Reviews on natural occurrence and biological properties of xanthone
dimers (15NPR6); natural occurrence, synthesis, and biological activities of
dihydrocoumarins (15OPP1); synthesis and structure–activity relationship
of natural and synthetic peloruside analogs (15CC4750) and of coumarin
derivatives (15EJM(101)476, 15NPR1472); and synthesis and bioactivities
of 1,4-benzodioxane lignans (15NPR1369) and of chroman-4-ones
(15EJM(93)539) have appeared. The synthesis and reactivity of
6-(trifluoromethyl)-2H-pyran-2-ones (15JFC36) and of furochromen-
4-ones (15EJM(90)633); synthesis and physical properties of π-expanded
coumarins (15JMCC1421); and isolation, biosynthesis, synthesis, and biological
activities of naphthopyranones (15NPR578) were also reviewed.
An overview on unconventional terpene cyclases and their impact on biomimetic biosynthesis of terpenoids bearing pyran and chroman moieties
(15AGE2604) and the chemical features, synthesis, and biological properties
of mangiferin and derivatives have appeared (15MRMC582). The background
and implications of natural antimalarial artemisinin in traditional
Chinese medicine (15NPR1617) as well as its synthesis, biosynthesis and
large-scale production (15NPR359) have been highlighted.
