Synthesis and transformation of halochromones uri icon


  • Chromones (4H-1-benzopyran-4-ones) are one of the most abundant groups of naturally occurring oxygen containing heterocyclic compounds possessing a benzo-γ-pyrone framework, 1a. The significance of these widely spread and highly diverse compounds is far beyond the important biological functions they assume in nature [1, 2]. Natural and synthetic chromone derivatives have been assigned as lead structures in drug development with some already being marketed [3]. The majority of the naturally occurring chromones are 2- and 3-aryl derivatives, called flavones 1b and isoflavones 1c, respectively. However, other types of chromones have also been found in the plant kingdom, such as 3-methylchromones 1d and 2- styrylchromones 1e (Fig. 1).
  • University of Aveiro, Fundação para a Ciência e a Tecnologia (FCT, Portugal), European Union, QREN, FEDER and COMPETE for funding the QOPNA Research Unit.

publication date

  • January 1, 2014