Conjugate additions of carbon nucleophiles to chromone derivatives towards nitrogen heterocycles
Conference Paper
Overview
Overview
abstract
Conjugate additions of
nitromethane to the extended π-
system of chromone derivatives
afforded the 1,6-conjugate
addition products, together with
structure complex oxygen
heterocycles through tandem
processes. Further
functionalization of targeted
adducts allowed the preparation
of biological relevant nitrogen
heterocycles such as
styrylpyrrolidines, as well as
pyrazole and bis-pyrazole
derivatives.
Thanks are due to FCT/MEC for the financial support of the QOPNA research unit (FCT
UID/QUI/00062/2013) through national founds and, where applicable, co-financed by the
FEDER, within the PT2020 Partnership Agreement, and to the Portuguese NMR Network.
H.M.T.A. is grateful to FCT for his PhD grant (SFRH/BD/86277/2012).
