Conjugate additions of carbon nucleophiles to chromone derivatives towards nitrogen heterocycles Conference Paper uri icon


  • Conjugate additions of nitromethane to the extended π- system of chromone derivatives afforded the 1,6-conjugate addition products, together with structure complex oxygen heterocycles through tandem processes. Further functionalization of targeted adducts allowed the preparation of biological relevant nitrogen heterocycles such as styrylpyrrolidines, as well as pyrazole and bis-pyrazole derivatives.
  • Thanks are due to FCT/MEC for the financial support of the QOPNA research unit (FCT UID/QUI/00062/2013) through national founds and, where applicable, co-financed by the FEDER, within the PT2020 Partnership Agreement, and to the Portuguese NMR Network. H.M.T.A. is grateful to FCT for his PhD grant (SFRH/BD/86277/2012).

publication date

  • January 1, 2017