Design, synthesis and preliminar antioxidant evaluation of new hydroxy- chromone and xanthone derivatives
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abstract
Chromone and xanthone derivativas are well-known for their outstanding antioxidant
properties. ln an effort to develop new antioxidants with improved efficacy, here we
cteveloped a new synthetic strategy to prepare hydroxylated chromones 3 and xanthones 4
with extended conjugated rr-systems. The synthetic strategy involved the aldolcondensation
of 2-methylchromones 1 with cinnamaldehyde 2 to give chromones 3.
Subsequent electrocyclization and oxidation of chromones 3 afforded xanthones 4 (Fig. 1 ).
The scavenging activities of both derivativas 3 and 4 were addressed against both reactive
oxygen species (ROS) and reactive nitrogen species (RNS). Ali tested compounds exhibited
scavenger effects dependent on the concentration, with ICso values found in the micromolar
range [1].
Sincere thanks are expressed to Faculdade de Farmácia da Universidade do Porto, Universidade de Aveiro, Instituto
Politécnico de Bragança, Fundação para a Ciência e a Tecnologia (FCT, Portugal), European Union, QREN, FEDER
and COMPETE funding UCIBIOREQUIMTE (FCT UID/Multi/04378/2013) and OOPNA (FCT UID/QUI/00062/2013)
Research Units and also to the Portuguesa National NMR Network (RNRMN).
