Tocopherols in Ginkgo biloba L.: A comparative study between infusion and dietary suplements Conference Paper uri icon


  • FCT for financial support to CIMO (PEst-OE/AGR/UI0690/2011) and L. Barros (Compromisso para a Ciencia 2008).
  • The concentrated extracts of Ginkgo biloba leaves have been marketed in Western countries as herbal medicines, which due to their bioactive compounds contribute for the improvement of cerebral blood flow and memory [1]. One of those compounds is α-tocopherol, which intervenes in the reduction of symptoms associated with oxidative stress in neurodegenerative disorders, particularly Alzheimer's disease. α-Tocopherol, an isoform of the lipid soluble vitamin E, is well-known as an antioxidant, and has been widely investigated as a potential prophylactic dietary supplement in cardiovascular diseases [2,3]. The objective of this study was to evaluate the amount and profile of tocopherols in some dietary supplements: pills based on G. biloba leaves standardized extract with 24% glycosides and 6% terpenes (P1, 40 mg/pill; P2, 60 mg/pill; and P3, 100 mg/pill); oral solution (OS- 40 mg of G. bilobo standardized extract/mL); and compare them with the infusion of G. bi/obo wild leaves (LI). Tocopherols were identified and quantified by high performance liquid chromatography coupled to a fluorescence detector (H PLCfluorescence). All the vitamers α-, β-, γ- and δ-tocopherol were found in the infusion, but not in dietary supplements. Furthermore, the infusion gave the highest amount of total tocopherols (126.23 mg/100 g dw) and of each individual vitamer; α-tocopherol was, by far, the most abundant tocopherol in that sample (124.88 mg/100 g dw). This study showed that wild G. bi/obo infusion supplies a much higher amount of tocopherols than dietary supplements based on the same plant. Moreover, its consumption could be beneficial due to the capacity of α-tocopherol to eliminate reactive oxygen species, inhibit lipid peroxidation, and attenuate inflammatory reactions.

publication date

  • January 1, 2013