publicações selecionadas
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artigo de revista
- Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: Discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors. Bioorganic & Medicinal Chemistry. 2015
- Antioxidant activity of aminodiarylamines in the thieno[3,2-b]pyridine series: Radical scavenging activity, lipid peroxidation inhibition and redox profile. Journal of Enzyme Inhibition and Medicinal Chemistry. 2014
- 1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR-2 tyrosine kinase inhibitors: Synthesis, biological evaluation, and molecular modelling studies. BioMed Research International. 2013
- New di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, growth inhibitory activity on human tumor cell lines and non-tumor cells, effects on cell cycle and on programmed cell death. European Journal of Medicinal Chemistry. 2013
- Aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, effects in human tumor cells growth, cell cycle analysis, apoptosis and evaluation of toxicity using non-tumor cells. Molecules. 2012
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artigo de conferência
- New di(hetero)aryl)ethers and Di(hetero)arylamines in the thieno[3,2-b]pyridine series: synthesis, growth inhibitory activity on tumor cell lines and non tumor cells, effects on cell cycle and on apoptosis 2014
- Synthesis, molecular Docking and biological evaluation of new 1-Aryl-3-[3-(thieno[3,2-b]pyridin-7-ylthio)phenylureas as Potent Type II VEGFR-2 Tyrosine Kinase inhibitors 2014
- Synthesis of new n-[3-(thieno[3,2-b]pyridine-7-ylthio)phenyl]benzamides as potential inhibitors of VEGFR2 using rational design 2013
- Epidermal growth factor receptor inhibitory activity of new potential antitumor di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series 2013
- New di(heteroaryl)thioethers 1,3-diarylureas in the thieno[3,2-b]pyridine series as VEGFR2 tyrosine kinase inhibitors: docking, synthesis, enzymatic and cellular assays 2013
- Synthesis and evaluation of the antitumor potential of new aminated or methoxylated di(hetero)arylthioethers in the thieno[3,2-b]pyridine series 2013
- Synthesis of new N-[3-(thieno[3,2-b]pyridine-7-ylthio)phenyl]benzamides as potential inhibitors the tyrosine kinase domain of VEGFR2 2013
- Heteroarylether 1,3-diarylureas in the thieno[3,2-d]pyrimidine series as VEGFR2 tyrosine Kinase inhibitors: Synthesis, docking studies, enzymatic and cellular assays 2012
- Synthesis, growth inhibitory activity on human tumor cell lines and evaluation of the hepatotoxicity of di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series. 2012
- 1-Aryl-3-[ 4-( thieno[3,2-d]pyrimidin-4-yloxy )phenyl]ureas as VEG FR2 inhibitors: synthesis, docking enzymatic and cellular assays 2012
- 1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR2 tyrosine kinase inhibitors: synthesis, docking studies, enzymatic and cellular assays 2012
- Synthesis of novel 1-aryl-3-[2,3- or 4-(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas and evaluation as VEGFR2 tyrosine kinase inhibitors 2012
- Synthesis, docking, enzymatic and cellular assays of thieno[3,2-b]pyridine-thioether-1,3-diarylureas as VEGFR2 inhibitors 2012
- Thieno[3,2-b]pyridine arylethers: synthesis and growth inhibitory activity on human tumor cell lines 2012
- Methyl 3-[4-(3-arylureido)phenylamino]thieno[3,2-b]pyridine-2-carboxylates as potential inhibitors of VEGFR-2: synthesis and molecular modelling studies 2011
- Methyl 3-amino-6-[4 or 3 or 2-(3-arylureido)phenyl]thieno[3,2-b]pyridine-2-carboxylates: synthesis and molecular modelling studies using VEGFR-2 2011
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documento
- Antiangiogenic effects of new di(hetero)arylthioethers 1,3-diarylureas in the thieno[3,2-b]pyridine series. Role in VEGFR-2 inhibition. 2013
- New di(heteroaryl)thioethers 1,3-diarylureas in the thieno[3,2-b]pyridine series as VEGFR-2 tyrosine kinase inhibitors: docking, synthesis, enzymatic and celular assay. 2013