Wild mushroom extracts as inhibitors of bacterial biofilm formation
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abstract
Introduction: Microorganisms can colonize a wide variety of medical
devices, putting patients in risk for local and systemic infectious
complications. These microorganisms are able to grow adhered
to almost every surface, forming biofilms. The use of natural
products has been successful in the discovery of new medicine, and
mushrooms could be a source of natural antimicrobials.
Objectives: The present study reports the capacity of wild mushroom
extracts to inhibit in vitro biofilm formation by multi-resistant
bacteria.
Methods: Four Gram-negative bacteria biofilm producers
(Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa and
Acinetobacter baumannii) isolated from urine were used to verify
the activity of Russula delica, Fistulina hepatica, Mycena rosea,
Leucopaxilus giganteus and Lepista nuda extracts.
Results: The results obtained showed that all tested mushroom
extracts presented some extent of inhibition of biofilm production.
Pseudomonas aeruginosa was the microorganism with the highest
capacity of biofilm production, being also the most susceptible
to the extracts inhibition capacity (≥ 50%). Among the five tested
extracts against E. coli, Leucopaxillus giganteus (47.8%) and
Mycenas rosea (44.8%) presented the highest inhibition of bio lm
formation. The extracts exhibiting the highest inhibitory effect
upon P. mirabilis biofilm formation were Sarcodon imbricatus
(45.4%) and Russula delica (53.1%). Acinetobacter baumannii was
the microorganism with the lowest susceptibility to mushroom
extracts inhibitory effect on biofilm production.
Conclusions: This is a pioneer study since, as far as we know, there
are no reports on the inhibition of biofilm production by the studied
mushroom extracts and in particular against multi-resistant clinical
isolates.
