publicações selecionadas documento Anti-inflammatory activity of mushrooms extracts, identified phenolic acids and their possible metabolites 2015 Inhibition of the VEGFR-2 tyrosine kinase domain by witd Roman chamomile extracts and phenolic compounds 2015 New di(hetero)aryl)ethers and Di(hetero)arylamines in the thieno[3,2-b]pyridine series: synthesis, growth inhibitory activity on tumor cell lines and non tumor cells, effects on cell cycle and on apoptosis 2014 Synthesis, molecular Docking and biological evaluation of new 1-Aryl-3-[3-(thieno[3,2-b]pyridin-7-ylthio)phenylureas as Potent Type II VEGFR-2 Tyrosine Kinase inhibitors 2014 Virtual screening of thieno[3,2-b]pyridine arylthioether (hetero)aryltriazole derivatives as potential tyrosine kinase VEGFR2 inhibitors. 2013 Epidermal growth factor receptor inhibitory activity of new potential antitumor di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series 2013 New di(heteroaryl)thioethers 1,3-diarylureas in the thieno[3,2-b]pyridine series as VEGFR2 tyrosine kinase inhibitors: docking, synthesis, enzymatic and cellular assays 2013 Synthesis and evaluation of the antitumor potential of new aminated or methoxylated di(hetero)arylthioethers in the thieno[3,2-b]pyridine series 2013 Synthesis of new N-[3-(thieno[3,2-b]pyridine-7-ylthio)phenyl]benzamides as potential inhibitors the tyrosine kinase domain of VEGFR2 2013 Synthesis, growth inhibitory activity on human tumor cell lines and evaluation of the hepatotoxicity of di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series. 2012 1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR2 tyrosine kinase inhibitors: synthesis, docking studies, enzymatic and cellular assays 2012 Heteroarylether 1,3-diarylureas in the thieno[3,2-d]pyrimidine series as VEGFR2 tyrosine Kinase inhibitors: synthesis, docking studies, enzymatic and cellular assays 2012 Synthesis of novel 1-aryl-3-[2,3- or 4-(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas and evaluation as VEGFR2 tyrosine kinase inhibitors 2012 Thieno[3,2-b]pyridine arylethers: synthesis and growth inhibitory activity on human tumor cell lines 2012 Methyl 3-[4-(3-arylureido)phenylamino]thieno[3,2-b]pyridine-2-carboxylates as potential inhibitors of VEGFR-2: synthesis and molecular modelling studies 2011 Rational design of thieno[3,2-b]pyridines as potential new VEGFR-2 inhibitors based on improved docking scores. 2011
investigador principal New antitumor and antiangiogenic heterocyclic compounds: synthesis, molecular modeling, screening of enzymatic inhibition and studies in tumor and endothelial cell lines with tyrosine kinase membrane receptors as targets. concedido pelo Fundacao para a Ciencia e a Tecnologia 2014 Metal-assisted synthesis and cyclisation of new biologically active and/or fluorescent aryl and heteroaryl amino acid derivatives concedido pelo Fundacao para a Ciencia e a Tecnologia 2008
