Exploring the powerful phytoarsenal of white grape marc against bacteria and parasites causing significant diseases
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abstract
Natural extracts containing high polyphenolic concentration possess antibacterial, anti-parasitic and fungicidal activities. The present research characterises two extracts based on white grape marc, a winemaking by-product, describing their physicochemical features and antimicrobial capacities. The main components of these extracts are phenolic acids, flavan-3-ols and their gallates and flavonols and their glycosides. As a result of this complex composition, the extracts showed pronounced bioactivities with potential uses in agricultural, pharmaceutical and cosmetic industries. Polyphenol compounds were extracted by using hydro-organic solvent mixtures from the by-product of Albariño white wines (Galicia, NW Spain) production. The in vitro antimicrobial activity of these extracts was evaluated on Gram-positive and Gram-negative bacteria and Apicomplexan and Oomycota parasites. Microbial species investigated are causing agents of several human and animal diseases, such as foodborne illnesses (Bacillus cereus, Escherichia coli, Salmonella enterica, and Toxoplasma gondii), skin infections and/or mastitis (Staphylococcus aureus and Streptococcus uberis), malaria (Plasmodium falciparum) and plant infections as “chestnut ink” or “root rot” (Phytophthora cinnamomi). Both extracts showed activity against all the tested species, being nontoxic for the host. So, they could be used for the development of biocides to control a wide range of pathogenic agents and contribute to the enhancement of winemaking industry by-products.
Natural extracts containing high polyphenolic concentration possess antibacterial, antiparasitic and
fungicidal activities. The present research characterises white grape marc, a winemaking by-product
describing their physicochemical features and antimicrobial capacities. Main components of 2 different
extracts generated were phenolic acids, flavan-3-ols and their gallates, and flavonols and their glycosides.
As a result of this complex composition white grape marc extracts showed pronounced bioactivities with
potential uses in agricultural, pharmaceutical and cosmetic industries, among others. Specifically,
polyphenol compounds were extracted by using hydro-organic solvent mixtures from the by-product of
Albariño white wines (Galicia, NW Spain) production. In the present work the “in vitro” antimicrobial
activity of the bioactive extracts was evaluated using two different hydro-organic mixtures (HOL & HOP).
The microorganisms tested included Gram positive and negative bacteria, two Apicomplexan parasite
species and one Oomycota parasite. Microbial species investigated are causing agents of several human
and animal diseases, such as foodborne illnesses (Bacillus cereus, Eschericha coli, Salmonella enterica),
skin infections (Staphylococcus aureus), mastitis (Streptococcus uberis), parasite infections as Malaria
(Plasmodium falciparum) or Toxoplasmosis (Toxoplasma gondii), and plant infections as "chestnut ink" in
chestnuts or "root rot" in avocado, both diseases caused by Phytophthora cinnamomi. Both extracts verified
activity against all the tested species demonstrating their potentiality to be used for the development of
biocides to control a wide range of pathogenic agents; at the same time that they contribute to winemaking
industry residues valorisation
This research was supported by projects GPC2017/04 (Consolidated Research Groups
Program) & ED431E 2018/01 Cross-Research in Environmental Technologies (CRETUS) (Xunta de Galicia, Spain)
