The purpose of this study was to learn the interplay between dry-land strength and conditioning, and stroke biomechanics in young swimmers, during a 34-week training programme. Twenty-seven swimmers (overall: 13.33 ± 0.85 years old; 11 boys: 13.5 ± 0.75 years old; 16 girls: 13.2 ± 0.92 years old) competing at regional- and national-level competitions were evaluated. The swimmers were submitted to a specific in-water and dry-land strength training over 34 weeks (and evaluated at three time points: pre-, mid-, and post-test; M1, M2, and M3, respectively). The 100-m freestyle performance was chosen as the main outcome (i.e. dependent variable). The arm span (AS; anthropometrics), throwing velocity (TV; strength), stroke length (SL), and stroke frequency (SF; kinematics) were selected as independent variables. There was a performance enhancement over time (M1 vs. M3: 68.72 ± 5.57 s, 66.23 ± 5.23 s; Δ = -3.77%; 95% CI: -3.98;-3.56) and an overall improvement of the remaining variables. At M1 and M2, all links between variables presented significant effects (p < .001), except the TV-SL and the TV-SF path. At M3, all links between variables presented significant effects (p ≤ .05). Between M1 and M3, the direct effect of the TV to the stroke biomechanics parameters (SL and SF) increased. The model predicted 89%, 88%, and 92% of the performance at M1, M2, and M3, respectively, with a reasonable adjustment (i.e. goodness-of-fit M1: χ2/df = 3.82; M2: χ2/df = 3.08; M3: χ2/df = 4.94). These findings show that strength and conditioning parameters have a direct effect on the stroke biomechanics, and the latter one on the swimming performance.