O desenvolvimento de uma úlcera
crónica nos membros inferiores vai influenciar
a estabilidade da pessoa e, por conseguinte,
a saúde da própria família, exigindo para os
mesmos a aquisição de estratégias de coping
eficazes de modo a minimizar o impacto das suas repercussões, com vista ao equilíbrio.
Atendendo à cronicidade da úlcera, o papel do
enfermeiro é fulcral para facilitar a adaptação
às mudanças daí decorrentes e para fornecer
recursos e estratégias capazes de concorrer
para a melhoria do bem-estar da pessoa e sua
família
The flowers of Borago officinalis L. (Boraginaceae), commonly known as borage, are widely used as a culinary ingredient. The aim of this study was to assess the potential benefits of fresh borage flower extract related to antioxidant, neuroprotective and anti-aging properties. The extract was obtained by Soxhlet extraction with ethanol as a solvent, and fatty acids were detected by GC-FID. The antioxidant activity was evaluated in vitro through the DPPH, FRAP and ORAC assays. Regarding the fatty acid (FA) composition, the extract showed high amounts of polyunsaturated FA. The Neuro-2a cell line was used to determine the cytoprotective capacity of the extract subjected to oxidative stress (H2O2). Moreover, the model organism Caenorhabditis elegans was used to assess antioxidant activity, delayed ageing as well as cytoprotection and reduced β-amyloid toxicity. Cells treated with the extract and H2O2 showed a better response to oxidative stress than the control group, particularly in terms of mitochondrial activity (MTT assay), redox state (ROS formation) and the activity of antioxidant enzymes (catalase and superoxide dismutase). B. officinalis flower extract showed promising antioxidant activity in the selected models, without causing toxicity. Hence, the results obtained support the antioxidant properties of borage flowers in different bioassays using living organisms.
