Phenolic profile of Cynara scolymus L. and Silybum marianum(L.) Gaertn and related antimicrobial properties
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resumo
Cynara scolymus L. (artichoke) and Silybum marianum (L.)
Gaertn (milk thistle), belonging to the Asteraceae family, are
medicinal plants with well-reported antioxidant and
hepatoprotective effects. Widely consumed as infusions, these
plants can also be found in several formulations to allow an
easier consumption. The bioactivity of infusions, pills, and
syrups based on artichoke and milk thistle was previously
reported by our research group [1,2] and among the various
phytochemicals present in these dietary supplements, phenolic
compounds are pointed out as the most responsible for their
beneficial properties.
With the aim of studying the antimicrobial activity and possible
relation with the phenolic composition, two different
formulations of each plant were assessed (pills and syrups).
The phenolic profiles were obtained by HPLC-DAD-ESI/MS,
and the antimicrobial activity was performed with clinical
isolates from hospitalized patients, namely Escherichia coli,
Escherichia coli spectrum extended producer of β-lactamases
(ESBL), Proteus mirabilis, Pseudomonas aeruginosa, and
methicillin-resistant Staphylococcus aureus (MRSA).
