The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial J.A.P. All authors have read and agreed to the published version of the manuscript.
support by national funds FCT/MCTES to CIMO (UIDB/00690/2020) and to CEB (UIDB/04469/2020) units, as well as BioTecNorte operation (NORTE-01-0145-FEDER-000004), FUNDEDE BY European Regional Development Fund under the scope of Norte2020-Programa Operacional Regional do Norte. Nuno Rodrigues also thanks support by national funds FCT/MCTES to CIMO (UIDB/00690/2020) and to CEB (UIDB/04469/2020) units, as the national funding by FCT–Foundation for Science and Technology, P.I., through the Institutional scientific well as BioTecNorte operation (NORTE-01-0145-FEDER-000004), funded by the European Regional employment program contract.