Virtual screening of a library of natural compounds against COX-2 protein Conference Paper uri icon

abstract

  • The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to the CIMO (UIDB/00690/2020); to the European Regional Development Fund (ERDF) through the Competitiveness and Internationalization Operational Program for financial support to the project 100% Figo (POCI-01-0247-FEDER-064977). S. Heleno and M. Carocho thank FCT for their individual employment program–contract (CEECIND/ 00831/2018, CEECIND/03040/2017), and L.Barros also thanks to the national funding by FCT through the institutional scientificemployment program–contract for her contract. C. Shirashi thank the project 100% Figos.
  • The use of nonsteroidal anti-inflammatory drugs (NSAIDs) in treating inflammatory diseases has been widespread, especially in treating rheumatoid arthritis. NSAIDs act mainly by promoting the inhibition of cyclooxygenase enzymes (COX-1 and COX-2), inducing significant anti-inflammatory, analgesic, and antipyretic activity. However, recent data show that prolonged use of NSAIDs can lead to cardiovascular side effects. Thus, the present work aims to identify COX-2 inhibitors alternatives from natural sources, specifically mushrooms, as an alternative to conventional inhibitors

publication date

  • January 1, 2022