Separation of nadolol racemates by high pH reversed-phase simulated moving bed chromatography
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abstract
Nadolol is a pharmaceutical drug marketed as a mixture of four
stereoisomers, used to treat cardiovascular diseases. This drug is a
mixture of two pairs of racemates, therefore, its complete separation
represents a challenging task. Recently, our research group reported
the pseudo-binary separation of nadolol by SMB chromatography
using both coated Chiralpak AD and Chiralpak IA immobilized
chiral stationary phases. In this work, we present an alternative
strategy, implementing a first achiral separation step, by using C18
columns to perform the separation of the two pairs of nadolol
racemates under reversed-phase mode. Extensive experimental and
simulation results will be presented including solvent screening,
measurement of equilibrium and kinetic data, and both fixed-bed and
SMB preparative separations. Extensive experimental and simulation
results will be presented, including solvent screening, measurement
of equilibrium adsorption isotherms, breakthrough measurements,
and SMB (FlexSMB-LSRE unit) experimental preparative separation
using C18 columns.
This work is a result of project AIProcMat@N2020 - Advanced Industrial Processes and Materials for a Sustainable Northern Region of Portugal 2020”, with the reference NORTE-01-0145-FEDER-000006, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and of project POCI-01-0145-FEDER-006984 – Associate Laboratory LSRE-LCM funded by ERDF through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI) – and by national funds through FCT - Fundação para a Ciência e a Tecnologia
