Preparative separation of nadolol racemates using reversed-phase liquid chromatography
Conference Paper
Overview
Research
Additional Document Info
View All
Overview
abstract
Nadolol is a nonselective beta-adrenergic receptor antagonist ( -blocker) pharmaceutical drug, widely
used in the treatment of cardiovascular diseases, such as hypertension, ischemic heart disease (angina
pectoris), congestive heart failure, and certain arrhythmias. Its chemical structure has three stereogenic
centers which allows for eight possible stereoisomers. However, the two hydroxyl substituents on the
cyclohexane ring are fixed in the cis-configuration, which precludes four stereoisomers; in fact, two pairs
of enantiomers. Nadolol is presently marketed as an equal mixture of the four stereoisomers, designated
as the diastereoisomers,
There are still few published works concerning the separation of nadolol stereoisomers. Most of these
works refer the resolution at analytical scale and few refer the separation at preparative scale using the
simulated moving bed (SMB) technology [2-4]. This technology is generally based on the use of chiral
adsorbents which must have enough recognition for all the chiral species.
This work was financially supported by Project POCI-01-0145-FEDER-006984 - Associate Laboratory LSRE-LCM
- funded by FEDER funds through COMPETE2020 - Programa Operacional Competitividade e Internacionalização
(POCI) and by national funds through FCT - Fundação para a Ciência e a Tecnologia. This work was also cofinanced
by QREN, ON2 and FEDER through Project NORTE-07-0162-FEDER-000050.
