Optimization of the adsorption process for the analytical and preparative separation of Nadolol stereoisomers
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abstract
Financial support by the Portuguese R&D foundation FCT (Fundação para a Ciência e Tecnologia) and the European Community through FEDER ( project PTDC/EQU-EQU/119025/2010), is gratetefull acknowledeged
The screening of different solvents and solvents mixtures for the
analytical and preparative separation of nadolol stereoisomers
using two chiral stationary phases is presented.
The experimental results are analysed through different
strategies of liquid chromatographic separation depending on the
target compound to be separated from a quaternary chiral
racemic mixture.
The wide range of present results can be very useful both for the
analytical or preparative separation of nadolol in order to better
characterize the pharmacological and therapeutical behaviour of
all single stereoisomers of this beta-blocker pharmaceutical drug.
The screening of different solvents and solvents mixtures for the analytical and preparative separation of nadolol stereoisomers using two chiral stationary phases is presented.
The experimental results are analysed through different strategies of liquid chromatographic separation depending on the target compound to be separated from a quaternary chiral racemic mixture.
The wide range of present results can be very useful both for the analytical or preparative separation of nadolol in order to better characterize the pharmacological and therapeutical behaviour of all single stereoisomers of this beta-blocker pharmaceutical drug.
