In the last 12 years, Simulated Moving Bed (SMB) technology has received considerable
attention in both academic and industrial fields. The objective of this chapter is to introduce the SMB concept and to present the modeling strategies to simulate and to implement the design of SMB processes. Results will be shown, illustrating the influence of equilibrium adsorption isotherms and mass transfer resistances on SMB performance. At the end of the chapter, two examples of SMB-related techniques will be discussed: the Varicol process, to be used inSMBunits with a lownumber of chromatographic columns; and the pseudo-SMB
process, a modification of classic SMB operation to perform ternary separations.
