Chiral separation of nadolol stereoisomers by liquid chromatography : screening of mobile phase composition and SMB separation Conference Paper uri icon

abstract

  • This work describes a systematic approach to rapid development of simulated moving bed (SMB) chiral chromatographic separations. The presented methodology involves several pulse experiments using a single-column to screen the best mobile phase composition using a Chiralpak AD stationary phase and equilibrium adsorption data used to specify the initial flow rates of the SMB operation.

publication date

  • January 1, 2012