Complete separation of the quaternary mixture of nadolol stereoisomers using preparative and simulated moving bed chromatography
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abstract
The separation and purification of high added value products by liquid chromatography is a very
popular technique. The development of more stable and efficient stationary phases, together
with the design of innovative and more flexible separation processes, enhanced the use of
chromatographic processes, particularly at preparative and industrial scales through fixedbed
and simulated moving bed (SMB) technologies. Fixed-bed and SMB techniques are more and
more used in the separation of a wide range of products for the pharmaceutical, fine chemistry,
biotechnology and food industries. In this context, one of the actual main challenges concerns
the design and optimization of these chromatographic processes for challenging
multicomponent separations. This includes the development of new and innovative
chromatographic processes, combining different design strategies and modes of operation, with
different types of stationary and mobile phases.
This work was financially supported by: Base Funding - UIDB/00690/2020 of CIMO - Centro de
Investigação de Montanha - funded by national funds through FCT/MCTES (PIDDAC), and Base
Funding - UIDB/50020/2020 of the Associate Laboratory LSRE-LCM - funded by national funds
through FCT/MCTES (PIDDAC).
This work is also a result of: Project - Advanced Industrial Processes and
-01-
0145-FEDER-000006, supported by Norte Portugal Regional Operational Programme (NORTE
2020), under the Portugal 2020 Partnership Agreement, through the European Regional
Development Fund (ERDF).
Rami S. Arafah is supported by a PhD Grant of Fundação para a Ciência e a Tecnologia
(SFRH/BD/137966/2018).
