Methodologies for the separation of chiral drugs by liquid chromatography: from analytical to preparative scale
Artigo de Conferência
Visão geral
Pesquisas
Informação adicional documento
Ver Todos
Visão geral
resumo
The main goal of the present work is to clear demonstrate that the selection of the proper solvent composition is a key step for both analytical and preparative separations. A complete methodology developed in the last years inside the LSRE group will be described. Three real optimization case-studies will be presented: two non-steroidal anti-inflammatory drugs (the separation of ketoprofen and flurbiprofen enantiomers) and one antihypertensive drug (the separation of nadolol stereoisomers).
