Separation of nadolol stereoisomers by liquid chromatography : screening of the mobile phase composition
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abstract
The screening of the most convenient mobile phase composition is presented for the chiral separation of the four stereoisomers of the beta-blocker drug nadolol. When the final goal is the preparative chiral separation, this selection is critical, since solubility, selectivity and retention are all
parameters very sensitive with mobile phase composition. Experimental results will show that the best mobile phase composition is, generally, very different if we consider an analytical or a preparative separation point of view.
