Bioactivity evaluation of four technical lignins: Alcell, Indulin-AT, Sarkanda and Curan 27-11P
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abstract
In what concerns bioactive properties, and due to its phenolic
character, lignin is mostly studied for their antioxidant activity.
In this work four technical lignins (Alcell, Indulin-AT, Sarkanda
and Curan 27-11P) have been evaluated for their antioxidant
activity (DPPH radical scavenging activity, reducing power and
inhibition of β-carotene bleaching) and antitumor potential
against MCF-7, NCI-H460, HCT-15, HeLa and HepG2 cell
lines. Additionally, the toxicity for non-tumour cells (PLP2) was
also evaluated. The obtained results were correlated with the
chemical and structural features of the studied lignins. Based on
the achieved results, lignins of GS type, i.e. lignins rich in
syringyl phenol units and poor in p-hydroxyphenyl ones result in
better antitumor potential.
