Optimization of analytical and preparative separation of nadolol stereoisomers by liquid chromatography Conference Paper uri icon

abstract

  • The direct chromatographic resolution of enantiomers using chiral stationary phases (CSPs) is actually a very well established separation technique. Several reasons were responsible for the growing success of this technique. The continuous technical development of new chiral stationary phases (CSPs) combined with their commercial availability hás been, probably, the most relevant leverage issue. The chiral separation process is a complex task, governed by several diíferent interactions between the chiral solutes, the solvent and the CSP.

publication date

  • January 1, 2014