Microscale flow dynamics of red blood cells in microchannels: an experimental and numerical analysis
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abstract
The blood flow dynamics in microcirculation depends strongly on the
microvascular networks composed with short irregular vessel segments which are
linked by numerous bifurcations. This paper presents the application of a confocal
micro-PTV system to track RBCs through a rectangular polydimethysiloxane
(PDMS) microchannel with a bifurcation. By using a confocal micro-PTV system,
we have measured the effect of bifurcation on the flow behaviour of both
fluorescent particles diluted in pure water and RBCs in concentrated suspensions.
After performing simulations with the commercial finite element software package
POLYFLOW, some experimental results were compared with the numerical results
and the limitations of these simulations were outlined.
