Micro/Nanofluidic and lab-on-a-chip devices have been increasingly used in biomedical
research [1]. Because of their adaptability, feasibility, and cost-efficiency, these devices
can revolutionize the future of preclinical technologies. Furthermore, they allow insights
into the performance and toxic effects of responsive drug delivery nanocarriers to be
obtained, which consequently allow the shortcomings of two/three-dimensional static
cultures and animal testing to be overcome and help to reduce drug development costs and
time [2–4]. With the constant advancements in biomedical technology, the development of
enhanced microfluidic devices has accelerated, and numerous models have been reported.
Given the multidisciplinary of this Special Issue (SI), papers on different subjects
were published making a total of 14 contributions, 10 original research papers, and
4 review papers. The review paper of Ko et al. [1] provides a comprehensive overview
of the significant advancements in engineered organ-on-a-chip research in a general way
while in the review presented by Kanabekova and colleagues [2], a thorough analysis
of microphysiological platforms used for modeling liver diseases can be found. To get
a summary of the numerical models of microfluidic organ-on-a-chip devices developed in
recent years, the review presented by Carvalho et al. [5] can be read. On the other hand,
Maia et al. [6] report a systematic review of the diagnosis methods developed for COVID-19,
providing an overview of the advancements made since the start of the pandemic.
In the following, a brief summary of the research papers published in this SI will be presented,
with organs-on-a-chip, microfluidic devices for detection, and device optimization
having been identified as the main topics.
